Alpha-Tocopheryl Nicotinate

Alpha-Tocopheryl Nicotinate has revealed some antiarrhythmic activity. Alpha-Tocopheryl Nicotinate is used in Europe and Japan for lipid-lowering means.

Using nicotinic acid as an antihyperlipidemic agent should be done under medical supervision. Individuals with a past history of gastritis, hepatobiliary disease, jaundice, or peptic ulcer disease should exercise caution in the use of high-dose nicotinic acid. Individuals with a history of cardiovascular disease, diabetes, gout, and renal dysfunction should be careful in the use of high-dose nicotinic acid. Individuals who consume large amounts of alcohol should also be careful in the use of high-dose nicotinic acid. Nicotinic acid is able to cause vasodilation of cutaneous blood vessels resulting in increased blood flow (mainly in the chest, face, and neck). This produces the niacin-flush. The niacin-flush is believed to be mediated via the prostaglandin prostacyclin. Histamine might also play a part in the niacin-flush. Flushing is the adverse reaction first observed after taking a large dose of nicotinic acid. It is the main reason for compliance issues with the use of high-dose nicotinic acid for the treatment of hyperlipidemia. Nicotinamide does not appear to be linked with flushing. High-dose Nicotinamide doesn't possess antihyperlipidemic activity. Symptoms of flushing include a burning, tingling and itching sensation. A reddened flush occurs mainly on the arms, chest, and face. Flushing is often accompanied by pruritis and headaches. This website is intended to educate and inform, and should not replace discussions with your doctor.