| Even though oxalic acid is formed when ascorbic acid is metabolized, this is highly unlikely
to cause renal problems in healthy people without preexisting renal problems or individuals
who are not predisposed to increased crystal aggregation. Individuals with preexisting
kidney stone disease or a history of renal insufficiency, should be careful in the use of
higher than RDA amounts of vitamin C. Ascorbic acid is involved in modulating iron
absorption and transport. It is very unlikely that healthy people who take supplemental
vitamin C will have any problems with iron overload. Those with hemochromatosis,
thalassemia, sideroblastic anemia, sickle cell anemia, and erythrocyte G6PD deficiency may
have such a problem if they take large quantities of vitamin C. Nursing mothers and women
who are pregnant should avoid using supplemental doses of vitamin C higher than RDA amounts.
Oral doses up to 3 grams daily of vitamin C are not likely to cause adverse reactions in
healthy adults. The most common adverse reaction in those taking oral doses greater than 3
grams daily are gastrointestinal and include abdominal cramps, diarrhea, flatulent
distention, and nausea. This website is intended to educate and inform, and should not
replace discussions with your doctor. |