| Nursing mothers and women who are pregnant should avoid doses of Copper above the upper
limit of the stated safe and adequate daily dietary intake, which for adults is 1.5 to 3.0
milligrams daily. Individuals with chronic liver failure and chronic renal failure should
apply extreme caution in the use of Copper supplements. Copper in gram amounts is extremely
toxic. Accidental Copper poisoning has occurred in children. Excessive Copper intake
produces diarrhea, epigastric pain, nausea, and vomiting. Concurrent use of penicillamine
and Copper can cause lowered absorption of both substances. Individuals who use
penicillamine to treat Wilson's disease should avoid using supplemental Copper. Excessive
intake of nonheme iron might decrease Copper status. Excessive intake of molybdenum might
lower Copper status. Excessive use of zinc might cause decreased absorption of Copper.
Copper depletion was seen when supplements of 50 milligrams or more of zinc were given for
extended periods. Copper absorption wasn't affected by zinc doses of 16.5 milligrams daily
for extended periods. Vitamin C supplementation of 1,500 milligrams daily caused the
activity of the Copper transporting protein ceruloplasmin to go down. Vitamin C
supplementation of 600 milligrams daily also caused a decline in ceruloplasmin, although
Copper absorption wasn't impaired. Concurrent intake of Copper with foods rich in phytic
acid might lower the absorption of Copper. Diets high in fructose might lower Copper status.
This website is intended to educate and inform, and should not replace discussions with your
doctor. |