Eicosapentaenoic (EPA)

Eicosapentaenoic might be helpful in lowering elevated triglycerides in individuals who are hyperglyceridemic. Eicosapentaenoic might play a therapeutic role in individuals with cystic fibrosis to reduce disease severity. It might also play a role in type 2 diabetics in retarding the progression of diabetic nephropathy.

Eicosapentaenoic should be used with caution in individuals taking warfarin (Coumadin) and by individuals with hemophilia due to the possible antithrombotic activity. Eicosapentaenoic should be stopped before surgical procedures. Eicosapentaenoic supplements should be used by children, nursing mothers, and women who are pregnant only if recommended and monitored by a physician. There haven't been reports of serious adverse events in individuals taking Eicosapentaenoic supplements for prolonged periods of time. Side effects reported include mild gastrointestinal upsets such as diarrhea, eructation, halitosis, nausea, fishy smelling breath, skin, and even urine. The blood-thinning effects can cause easy bruising and occasional nosebleeds. Interactions might occur between Eicosapentaenoic supplements and aspirin and other non-steroidal anti-inflammatory drugs, and herbs such as garlic and ginkgo. Such interactions may be manifested by increased susceptibility to bruising, hematemesis, hematuria, hemoptysis, nosebleeds, and blood in the stool. Most people who take Eicosapentaenoic supplements and the above herbs or medicines don't suffer these problems and if they occur, they are rare. The Eicosapentaenoic dose should be lowered or discontinued if they do occur. Conflicting results have been reported on the effects of Eicosapentaenoic supplements on glycemic control in non-diabetics with glucose intolerance, and those with type 2 diabetes. Some of the early studies indicated that Eicosapentaenoic supplements may have detrimental effects in those groups. Recent studies have not reported these adverse effects. There isn't any evidence that Eicosapentaenoic supplements have detrimental effects on glucose tolerance, insulin secretion, or insulin resistance in non-diabetic individuals. Diabetics should discuss the use of these supplements with their physicians. Diabetics taking Eicosapentaenoic supplements should be monitored by their physicians. This website is intended to educate and inform, and should not replace discussions with your doctor.