Gamma-Tocopherol

Alpha- and Gamma-Tocopherol might have complementary antioxidant activities. In general, Gamma-Tocopherol is likely to have some or most of the same indications and uses as alpha-tocopherol, although it has not been as extensively studied as alpha-tocopherol. Gamma-Tocopherol might be more protective against cardiovascular disease than alpha-tocopherol. It could also be more effective in preventing some cancers. There is one recent report that elevated blood levels of Gamma-Tocopherol might be linked with an increased incidence of knee osteoarthritis.

Individuals taking warfarin should be cautious in using high doses of Gamma-Tocopherol and, if they do so, they should have their INRs carefully monitored and their warfarin doses appropriately adjusted if indicated. Individuals with vitamin K deficiencies, such as those with liver failure, should be cautious in using high doses of Gamma-Tocopherol. Gamma-Tocopherol should be used with caution in those with a history of hemorrhagic stroke, those with lesions with a propensity to bleed, and those with inherited bleeding disorders. High dose Gamma-Tocopherol supplementation should be stopped about one month before surgical procedures and can be continued after recovery from the procedure. Individuals taking iron supplements shouldn't take Gamma-Tocopherol concurrently with the iron. Gamma-Tocopherol has only recently been introduced into the nutritional supplement marketplace so no adverse reactions have been reported. High doses of Gamma-Tocopherol might potentiate the effects of antiplatelet drugs (such as abciximab, aspirin, clopidogrel, dipyridamole, eptifibatide, ticlopidine, and tirofiban). Cholestyramine, colestipol, isoniazid, and mineral oil might all lower Gamma-Tocopherol absorption. Neomycin might impair utilization of Gamma-Tocopherol. Orlistat is likely to inhibit Gamma-Tocopherol absorption. Sucralfate might interfere with Gamma-Tocopherol absorption. Supplemental alpha-tocopherol might lower plasma concentration of Gamma-Tocopherol. Desiccated ox bile might increase the absorption of Gamma-Tocopherol. Most iron supplements contain the ferrous form of iron. This form can oxidize Gamma-Tocopherol, which is marketed in a free, unesterified form, to its pro-oxidant form, if taken concurrently. Medium-chain triglycerides might enhance absorption of Gamma-Tocopherol if taken concurrently. Phytosterols and phytostanols, including beta-sitosterol and beta-sitostanol might decrease plasma Gamma-Tocopherol levels. Plant phenolic compounds and flavonoids might participate in redox cycling reactions and help maintain levels of reduced Gamma-Tocopherol. Selenium might function synergistically with Gamma-Tocopherol. Vitamin C might help maintain Gamma-Tocopherol in its antioxidant form. Olestra is likely to inhibit the absorption of Gamma-Tocopherol. Some herbs, including garlic and ginkgo, possess antithrombotic activity. High doses of Gamma-Tocopherol used concurrently with these herbs might enhance their antithrombotic activity. This website is intended to educate and inform, and should not replace discussions with your doctor.